Abstract

The alkylating agent melphalan (Hepzato – Delcath) has been approved by the FDA for treatment of uveal melanoma in adults with unresectable hepatic metastases that affects <50% of the liver and no extrahepatic disease, or extrahepatic disease limited to the bone, lymph nodes, subcutaneous tissues, or lung that is amenable to resection or radiation.

Full Text

Published Version
Open DOI Link

Topics from this Paper

  • Alkylating Agent Melphalan
  • Melanoma In Adults
  • Unresectable Hepatic Metastases
  • Extrahepatic Disease
  • Subcutaneous Tissues
    • + Show 5 more

Create a personalized feed of these topics

Get Started

Get access to 115M+ research papers

Discover from 40M+ Open access, 2M+ Pre-prints, 9.5M Topics and 32K+ Journals.

Sign Up Now! It's FREE

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Similar Papers

Radioembolization of unresectable hepatic metastases using yttrium-90 microspheres in heavily pretreated colorectal cancer.
  • Journal of Clinical Oncology
  • Feb 1, 2011
Relevant
Not Relevant
A Role for Hepatic-Directed Chemotherapy in Colorectal Liver Metastases
  • Journal of Clinical Oncology
  • Aug 1, 2005
Relevant
Not Relevant
Resection of non-hepatic colorectal cancer metastasis.
  • Journal of gastrointestinal oncology
  • Feb 2, 2012
Relevant
Not Relevant
Phase I trial of hepatic arterial infusion (HAI) of floxuridine with modified oxaliplatin, 5-fluorouracil and leucovorin (m-FOLFOX6) in Chinese patients with unresectable liver metastases from colorectal cancer
  • Cancer Chemotherapy and Pharmacology
  • Sep 13, 2014
Relevant
Not Relevant
A melanoma odyssey – a conversation with Vernon Sondak about a career in melanoma treatment and research
  • Melanoma Management
  • Sep 5, 2014
Relevant
Not Relevant
Phase I Study of Hepatic Arterial Infusion of Floxuridine and Dexamethasone With Systemic Irinotecan for Unresectable Hepatic Metastases From Colorectal Cancer
  • Journal of Clinical Oncology
  • May 15, 2001
Relevant
Not Relevant
In-transit melanoma: The role of alkylating-agent resistance in regional therapy1
  • Journal of the American College of Surgeons
  • Sep 1, 2004
Relevant
Not Relevant
New-onset uveitis during CTLA-4 blockade therapy with ipilimumab in metastatic melanoma patient
  • Canadian Journal of Ophthalmology
  • Feb 1, 2015
Relevant
Not Relevant
Selective internal radiation therapy for hepatic metastases of uveal melanoma: a systematic review
  • The British Journal of Radiology
  • Jan 1, 2022
Relevant
Not Relevant
Serum carcinoembryonic antigen (CEA) correlates with the survival time during 5-FU hepatic arterial infusion chemotherapy for unresectable colorectal hepatic metastases
  • International Journal of Oncology
  • Oct 1, 1996
Relevant
Not Relevant
Preface
  • Clinics in Plastic Surgery
  • Jan 1, 2010
Relevant
Not Relevant
Angiomyomatous hamartoma of the inguinal lymph nodes with localized lymphedema presenting as a soft subcutaneous mass
  • JAAD Case Reports
  • Sep 1, 2022
Relevant
Not Relevant
Combined Effects of Yttrium-90 Transarterial Radioembolization around Immunotherapy for Hepatic Metastases from Uveal Melanoma: A Preliminary Retrospective Case Series
  • Journal of Vascular and Interventional Radiology
  • Oct 1, 2018
Relevant
Not Relevant
Phase II study of ipilimumab (IPI) in children and adolescents with unresectable stage III or IV malignant melanoma (MEL).
  • Journal of Clinical Oncology
  • May 30, 2017
Relevant
Not Relevant
Biochemotherapy for the treatment of metastatic malignant melanoma: A systematic review
  • Cancer Treatment Reviews
  • Apr 1, 2008
Relevant
Not Relevant
READ MORE FROM

The Medical letter on drugs and therapeutics

Sulbactam/durlobactam (Xacduro) for Acinetobacter pneumonia.
Just Published
  • The Medical letter on drugs and therapeutics
  • Nov 27, 2023
Relevant
Not Relevant
Shockwave therapy for erectile dysfunction.
Just Published
  • The Medical letter on drugs and therapeutics
  • Nov 27, 2023
Relevant
Not Relevant
In brief: GI effects of GLP-1 receptor agonists.
Just Published
  • The Medical letter on drugs and therapeutics
  • Nov 27, 2023
Relevant
Not Relevant
Ritlecitinib (Litfulo) for severe alopecia areata.
Open Access
Just Published
  • The Medical letter on drugs and therapeutics
  • Nov 27, 2023
Relevant
Not Relevant
Addendum.
Just Published
  • The Medical letter on drugs and therapeutics
  • Nov 27, 2023
Relevant
Not Relevant
Etrasimod (Velsipity) for ulcerative colitis.
Open Access
Just Published
  • The Medical letter on drugs and therapeutics
  • Nov 27, 2023
Relevant
Not Relevant
COVID-19 update: New Novavax vaccine formulation for 2023-2024.
  • The Medical letter on drugs and therapeutics
  • Nov 13, 2023
Relevant
Not Relevant
Correction.
  • The Medical letter on drugs and therapeutics
  • Nov 13, 2023
Relevant
Not Relevant
In brief: Empagliflozin (Jardiance) for chronic kidney disease.
  • The Medical letter on drugs and therapeutics
  • Nov 13, 2023
Relevant
Not Relevant
Antiviral drugs for influenza for 2023-2024.
  • The Medical letter on drugs and therapeutics
  • Nov 13, 2023
Relevant
Not Relevant