Abstract
Objective. To investigate the IMRT treatment of nasopharyngeal carcinoma term effect, toxicity, and technical features. Methods. Sliding windows dynamic CT image-guided IMRT techniques on 31 patients for treatment of nasopharyngeal carcinoma radical radiotherapy, with 30 to 33 min irradiation. Target prescription dose GTVnx, GTVnd, CTV1, and CTV2 were 70∼76Gy, 68∼70Gy, 60∼66Gy, and 54Gy, while giving a dose of vital organs, the brain stem, and other restrictions to protect the parotid gland. Results. During 3 to 18 months of follow-up for a median period of 10 months, 1-year locoregional patients’ progression-free survival, distant metastasis-free survival, and overall survival rates were 93.5%, 87.1%, and 93.5%, respectively. Acute radiation reactions of grade I and II, xerostomia, and radioactive stomatitis were not observed. IMRT DVH analysis showed increased total dose and the irradiation target volume divided doses, reduced OARs illuminated, and the total dose divided doses. Conclusion. Intensity-modulated radiation therapy can achieve good short-term effects, significantly reduce the acute radiation response, and improve the quality of life of patients. It is worthy of promotion and application and in-depth research.
Highlights
Nasopharyngeal carcinoma is one of the common malignant tumors in China
Important challenges and issues: Intensity-modulated radiation therapy (IMRT) is an advanced radiotherapy technology that appeared at the end of the 20th century
It has the technical advantage of giving different doses to different areas at the same time to form a complex dose distribution. e application of IMRT in the treatment of nasopharyngeal cancer can improve the curative effect and reduce the sequela of radiotherapy
Summary
To investigate the IMRT treatment of nasopharyngeal carcinoma term effect, toxicity, and technical features. Sliding windows dynamic CT image-guided IMRT techniques on 31 patients for treatment of nasopharyngeal carcinoma radical radiotherapy, with 30 to 33 min irradiation. Acute radiation reactions of grade I and II, xerostomia, and radioactive stomatitis were not observed. IMRT DVH analysis showed increased total dose and the irradiation target volume divided doses, reduced OARs illuminated, and the total dose divided doses. Intensitymodulated radiation therapy can achieve good short-term effects, significantly reduce the acute radiation response, and improve the quality of life of patients. It is worthy of promotion and application and in-depth research
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