Abstract
Porous graphitic carbon (PGC) HPLC columns have been marketed for several years and have been shown to be superior to octadecyl silica columns for the separation of geometric isomers and closely related compounds. This makes them ideally suited to the determination of related substances and egradation products of drugs. In this study, PGC was used to improve the separation of related substances and degradation products of DPC 961, a new Non Nucleoside Reverse Transcriptase Inhibitor in development for the treatment of HIV infections. The porous graphitic carbon column dramatically improved the separation ofcis/trans isomeric related substances. In addition, the PGC column separated DPC 961 degradants which were not resolved from the main drug peak on a silica-based octadecyl column.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call