Impulse control disorders and its association to medication use and other associated factors in patients with Parkinson's disease

Abstract

Objectives: Impulse control disorders (ICDs) are behaviors that are performed repeatedly, to the point of interfering with the patient's functionality and daily life, without regard for their consequences and with the sole purpose of obtaining immediate gratification. ICDs have been have been related to dopaminergic treatment. This study analyzes the association of different risk factors for the development of ICD in the Mexican population.
 Methods: A cross-sectional study including 244 patients diagnosed with PD was carried out. The data collected were from the year 2021 to 2023. Data were collected through structured interviews including age, gender, year of symptom onset, year of diagnosis, levodopa equivalent dose, antiparkinsonian treatment, and history of smoking and alcohol use was evaluated.
 Results: 244 patients with a diagnosis of Parkinson's disease were included, of whom 146 (59.8%) were men and 98 (40.2%) women with a mean age of 63+/-12.10 years. The sample population was divided into two groups, Group 1 were patients with ICD(ICD-PD) (n=35), and Group 2 Non-ICD (n=209). ICD was associated with alcohol use 2.390 (95% CI 0.02 - 1.72).A trend was found for the use of dopamine agonists (p=0.07) No statistically significant difference was found between groups regarding smoking habits, age at diagnosis, age at symptom onset, age, diagnostic delay, and levodopa equivalent doses.
 Conclusions: Use of alcohol and agonist dopaminergic were the main associated risk factor after multivariate logistic regression.