Improving the organism's resistance to the stress “time deficiency” by iodine-containing thyroid hormones

Abstract

The high prevalence of diseases of stressful etiology and insufficient knowledge of the mechanisms of their pathogenesis, as well as factors limiting the intensity of the stress reaction, among which iodine-containing thyroid hormones have recently been studied, determine the relevance of the study. The purpose of the work is to study the effect of thyroid status on the organism's resistance to emotional stress. The experiment was performed on 180 white male rats weighing 220–240 g. Stress was modeled according to the “time deficiency” method, when the animal, trying to avoid contact with water quickly filling the spiral tunnel, was forced to move up. Statistical processing of the obtained results was carried out using generally accepted medical statistics methods using program “Statistica 10.0”. The introduction of mercazolyl (25 mg / kg for 20 days), which determines a lower concentration of iodine-containing thyroid hormones in the blood under stress, prevents an increase in the relative weight of the adrenal glands and the corticosteroids level in the blood, an increase in physical endurance and horizontal motor activity of animals, inhibits their research behavior, and aggravates damage gastric mucosa in these conditions. The introduction of L-thyroxine in small doses (1.5-3 μg / kg 28 days) provides a higher level of iodine-containing thyroid hormones and increases the body's resistance to stress (limits the changes in the relative weight of the adrenal glands, spleen and thymus, corticosteroids and insulin levels in the blood , behavior and physical endurance of animals, damage to the gastric mucosa). Iodine-containing thyroid hormones increase the body's resistance to stress of the “time deficiency”, which proves their important role in the body's anti-stress system.