Abstract
In elderly men, benign prostatic hyperplasia (BPH) is a major risk factor for sexual dysfunctions (SDys). Additionally, the standard treatments for BPH symptoms, alpha blockers and 5-alpha-reductase inhibitors, cause SDys themselves. Preparations from saw palmetto berries are an efficacious and well-tolerated symptomatic treatment for mild to moderate BPH and have traditionally been used to treat SDys. We conducted an open multicentric clinical pilot trial to investigate whether the saw palmetto berry preparation Prostasan® influenced BPH symptoms and SDys. Eighty-two patients participated in the 8-week trial, taking one capsule of 320 mg saw palmetto extract daily. At the end of the treatment, the International Prostate Symptom Score was reduced from 14.4 ± 4.7 to 6.9 ± 5.2 (p < 0.0001); SDys measured with the brief Sexual Function Inventory improved from 22.4 ± 7.2 to 31.4 ± 9.2 (p < 0.0001), and the Urolife BPH QoL-9 sex total improved from 137.3 ± 47.9 to 195.0 ± 56.3 (p < 0.0001). Investigators' and patients' assessments confirmed the good efficacy, and treatment was very well tolerated and accepted by the patients. Correlation analyses confirmed the relationship between improved BPH symptoms and reduced SDys. This was the first trial with saw palmetto to show improvement in BPH symptoms and SDys as well. [Corrections made here after initial online publication.]
Highlights
We investigated if the saw palmetto (Serenoa repens) preparation Prostasan® is efficacious and safe in treatment of patients with (BPH) and concomitant sexual dysfunctions
At the end of the treatment, Benign prostatic hyperplasia (BPH) symptoms measured with the International Prostate Symptom Score was reduced from 14.4 ± 4.7 to
Sexual dysfunctions assessed with the brief Sexual Function Inventory improved from 22.4 ± 7.2 to 31.4 ± 9.2 (P < 0.0001), and the Urolife BPH QoL‐9 total improved from 162.7 ± 47.9 to 105.0 ± 56.3 (P < 0.0001)
Summary
Improving BPH symptoms and sexual dysfunctions with a saw palmetto preparation? Benign prostatic hyperplasia (BPH) is one of the main factors to cause sexual dysfunctions in elderly men. We investigated if the saw palmetto (Serenoa repens) preparation Prostasan® is efficacious and safe in treatment of patients with (BPH) and concomitant sexual dysfunctions. Eighty-two patients participated in the 8‐week trial, taking one capsule of 320 mg saw palmetto extract daily.
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