Abstract
The aim of the study was to assess the possibility of fixed combination Lisinopril + amlodipine + rozuvastatin to improve arterial elesticity in patients with hypertension and high pulse wave velocity, despite previous diuretic-based combination antihypertensive therapy. Materials and methods. In an open, observational study duration of 24 weeks was included 60 patients on previous diuretic-based combination antihypertensive therapy. All participants underwent 24-hour blood pressure monitoring, applanation tonometry (augmentation index and central blood pressure), pulse wave velocity measurement, laboratory tests (lipid profile, fasting glucose, insulin resistance index - NOMA), leptin, high-sensitivity C-reactive protein before and after the switching to a fixed combination of lisinopril + amlodipine + rosuvastatin. Results. According to measurements of office blood pressure switching of patients on double combinations based on diuretics to a fixed combination of lisinopril + amlodipine + rosuvastatin, a further decrease in systolic blood pressure (SBP) by 13.7% and diastolic BP (DBP) by 18.8% was observed. According to the ABPM, the decline in the average daily SBP was 15.8%, DBP - 22.5%, average SBP - 16.2%, DBP - 19.8%. The combination of lisinopril + amlodipine + rosuvastatin reduced PWV by 15.9%, augmentation index by 13.5%, central SBP by 8.4% (p
Highlights
В настоящее время доказана взаимосвязь улучшения показателей эластичности сосудов различного калибра, выживаемости и снижения риска развития сердечно-сосудистых осложнений при артериальной гипертензии (АГ) [1]
The aim of the study was to assess the possibility of fixed combination Lisinopril + amlodipine
to measurements of office blood pressure switching of patients on double combinations based on diuretics to a fixed combination
Summary
В настоящее время доказана взаимосвязь улучшения показателей эластичности сосудов различного калибра, выживаемости и снижения риска развития сердечно-сосудистых осложнений при артериальной гипертензии (АГ) [1]. И изменений показателей, характеризующих эластичность сосудов различного калибра (СПВ, индекс отраженной волны, центральное АД, толщина интима–медиа общей сонной артерии, потокзависимая вазодилатация), инсулинорезистентность и воспаление при переводе пациентов с двухкомпнентных антигипертензивных комбинаций, включающих в себя диуретик, на фиксированную комбинацию лизиноприл + амлодипин + розувастатин (Эквамер®, «Гедеон Рихтер»).
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