Abstract
Sensory ataxia is a type of ataxia that is caused by the loss of sensory input to control the movement of the body. It is both a sign and a symptom. There have been no curative modalities for treating sensory ataxia. Cellular therapy has gained significant attention as a therapeutic option for various neurological disorders. We present a case of an 18-year-old female diagnosed with sensory ataxia who was intrathecally administered with autologous bone marrow mononuclear cells (BMMNCs) along with neurorehabilitation. Twelve months after cellular therapy, signs such as ataxia, postural tremors, intention tremors and dysmetria improved. Functional Independence Measure score improved from 106 to 107. Berg Balance Scale improved from 18 to 34. Brief Ataxia Rating Scale improved from 7 to 5. Modified International Cooperative Ataxia Rating Scale improved 26 to 24. Comparison of the Positron Emission Tomography Computed-Tomography (PET CT) image before and 12 months after cellular therapy showed improved metabolism in bilateral sensory motor cortex, thalamus and cerebellum. These PET findings correlated with symptomatic improvements. The clinical improvements along with PET CT findings suggest that cellular therapy is a beneficial therapeutic modality for sensory ataxia. No major adverse effects were seen. Further clinical studies should be conducted to understand the efficacy of cellular therapy in sensory ataxia. 
 Keywords: Sensory ataxia; Cellular therapy; Autologous Bone Marrow Mononuclear Cells; Positron Emission Tomography Computed Tomography.
Highlights
Ataxia refers to incoordination of movements caused due to damage to several different nervous system structures
We present a case of an 18-year-old female diagnosed with sensory ataxia who was intrathecally administered with autologous bone marrow mononuclear cells (BMMNCs) along with neurorehabilitation
Case Representation: We present a case of an 18-year-old female diagnosed with sensory ataxia since 3 years
Summary
Ataxia refers to incoordination of movements caused due to damage to several different nervous system structures. It may result from cerebellar, vestibular or sensory (proprioceptive) dysfunction. Sensory ataxias involve disorders that affect the sensory fibers or their connections with the neuraxis causing loss of proprioception [1]. Sensory ataxia is often misdiagnosed as cerebellar ataxia. Sensory ataxia is distinguishable from cerebellar ataxia as. [3] The progressive loss of myelin may lead to chronic demyelination, impairing the normal axonal conduction velocity and causing sensory ataxia. [4] There is yet no cure available for sensory ataxia. Newer treatments to cure ataxia should focus on addressing the core neuropathology of the disorder
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