Abstract
SUMMARY The hairless mouse screening model for antipsoriatic drugs was improved by investigating the effects of critical variables on the rate of ultraviolet light-induced epidermal DNA synthesis. The variables investigated were diurnal variation, ultraviolet light dose, time course and ambient temperature. From these studies a set of experimental conditions was developed that resulted in the lowest rate of DNA synthesis in non-irradiated epidermis and the highest rate in irradiated epidermis, thereby significantly increasing the power of the assay.
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