Abstract
An approach to Hadamard phase encode the two halves of the F(1) dimension of a gHSQC experiment is presented. The phase encoding is achieved by excitation sculpting of the F(1) dimension using symmetrically shifted pulses. This approach (IMPRESS-improved resolution using symmetrically shifted pulses) increases the resolution of the F(1) dimension by exploiting spectral folding, but the folding is coded in the fashion of a Hadamard H(2) matrix. Editing of the IMPRESS spectra during processing sorts out spectral crowding which is a typical consequence of F(1) spectral folding. It is shown that for the same total experiment time, the IMPRESS-gHSQC experiment provides narrower peaks along the F(1) dimension compared to the normal gHSQC experiment. As a consequence of decreased linewidth, the peak height (sensitivity) is also increased.
Published Version
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