Improved operation of a dextran bioreactor-separator through variation of enzyme activity, viscosity, centrifugal parameters and rotor design

Abstract

Viscosity regulation allowed the sedimentation of dextran to be increased from 1.89 to 2.89 g.h−1 within a novel centrifugal bioreactor. At an enzyme activity of 187 U, dextran pelleting was 1.66 mg g.h−1. U which was 50% greater than at an enzyme activity of 1344 U. Reactor productivity, at 1.5–2 g.h−1, was similar for both batch and semi-continuous trials. Rotor core design influenced productivity. © Rapid Science Ltd. 1998