Improved Lipid Profile Associated with Daily Consumption of Tri-Sura-Phon in Healthy Overweight Volunteers: An Open-Label, Randomized Controlled Trial.

Sirigoon Kuamsub,Sasitorn Chusri,Pariyaphat Singthong,Wipawee Chanthasri,Thammarat Kaewmanee,Sasithorn Hemdecho,Nicharee Chobngam,Warissara Sangkaew

doi:10.1155/2017/2687173

Abstract

Tri-Sura-Phon (TSP), a traditional Thai polyherbal formula renowned for its rejuvenating properties, is commonly used as a blood tonic. It comprises Cinnamomum bejolghota, Cinnamomum parthenoxylon, and Aquilaria crassna. The aim of this study is to evaluate the beneficial properties of TSP tea consumption on blood glucose regulation and serum lipid profiles of healthy overweight volunteers. This open-label, randomized controlled trial was conducted in 70 healthy overweight adults. Two groups of 35 subjects took a TSP infusion or a placebo (cornstarch) twice daily for 8 weeks. The blood glucose regulation, serum lipid profiles, BMI, and liver function tests of the subjects were determined at the baseline, 4th week, and endpoint (8th week). Significant decreases in the average fasting levels of total cholesterol (p = 0.013), triglyceride (p = 0.001), and low-density lipoprotein (LDL, p = 0.017) were observed in the TSP group at the 8th week compared to those at the baseline. The average HDL level in the TSP group at the beginning of the study was 65.2 mg/dL, and it increased significantly (p = 0.005) to 72.4 mg/dL after 8 weeks of TSP intake. This study showed that the intake of TSP tea as an antioxidant-rich beverage might be safe and improve lipid profiles in overweight adults.

Highlights

Obesity has become a major global health concern because it is directly related to the incidence of type 2 diabetes [1], hypertension, hypercholesterolemia [2], acceleration of aging process [3], and arteriosclerosis
In vivo studies have clearly demonstrated that treating obese animal models with antioxidant agents attenuates the development of hyperlipidemia and diabetes [5, 6]
The present results showed that an 8-week period of TSP tea drinking (2 cups per day) safely improves serum lipid profiles in overweight or obese volunteers

Summary

Introduction

Obesity has become a major global health concern because it is directly related to the incidence of type 2 diabetes [1], hypertension, hypercholesterolemia [2], acceleration of aging process [3], and arteriosclerosis. Obesity is associated with significant increases in oxidative stress owing to the well-established relationship between oxidative stress and metabolic syndrome [4]. In vivo studies have clearly demonstrated that treating obese animal models with antioxidant agents attenuates the development of hyperlipidemia and diabetes [5, 6]. Some traditional medicinal plants that possess antioxidant activity and contain high amounts of phenolics are green tea (Camellia sinensis) [7], Salvia officinalis [8], Melissa officinalis [9], and Capparis spinosa [10].

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