Abstract
Background: Regular physical activity is recognized as a non-pharmacological treatment of inflammation and glycemic profile. Objectives: This exercise aimed to determine the effect of aerobic training on serum interleukin-6 (IL-6), glucose and insulin resistance in obese females. Patients and Methods: Thirty-two middle-aged obese women (body mass index [BMI], 32 ± 3 kg/m2) aged 35 to 45 years were randomly assigned to exercise (aerobic training, n=16) and control (n=16) groups. Exercise subjects were completed a 12 weeks aerobic training program as 3 sessions per week at 60%-80% of HRmax and control subjects received no training. Pre- and post-training of fasting serum IL-6, insulin, insulin resistance, and glucose concentration were measured and compared between 2 groups. Results were compared using t test at a significance level of P<0.05. Results: Exercise group obtained significant decreases in BMI, body fat %, and abdominal obesity as well as the concentrations of serum IL-6 and fasting glucose (P<0.05). No significant difference was observed between pre- and post-training of insulin and insulin resistance in the exercise group (P >0.05). There were no alterations in these variables in the control group (P>0.05). Conclusions: These data suggest that aerobic training may improve glycemic profile in absence of change in insulin resistance of women with abdominal obesity
Highlights
Regular physical activity is recognized as a non-pharmacological treatment of inflammation and glycemic profile
This study aims to examine the effects of a 12-week aerobic training program on serum levels of IL-6 as well as glucose and insulin resistance in sedentary overweight women
Confirming the impact of weight loss or body fat percentage on the inflammatory profile, especially in obese people [31,32], the findings of the present study showed that regular aerobic training for 12 weeks significantly reduced the inflammatory cytokines of obese women
Summary
Regular physical activity is recognized as a non-pharmacological treatment of inflammation and glycemic profile. Objectives: This exercise aimed to determine the effect of aerobic training on serum interleukin-6 (IL-6), glucose and insulin resistance in obese females. Pre- and post-training of fasting serum IL-6, insulin, insulin resistance, and glucose concentration were measured and compared between 2 groups. Results: Exercise group obtained significant decreases in BMI, body fat %, and abdominal obesity as well as the concentrations of serum IL-6 and fasting glucose (P < 0.05). No significant difference was observed between pre- and post-training of insulin and insulin resistance in the exercise group (P > 0.05). Conclusions: These data suggest that aerobic training may improve glycemic profile in absence of change in insulin resistance of women with abdominal obesity. Clinical studies in adults have demonstrated that chronic inflammation is effective in the pathogenesis of diseases such as atherosclerosis [6], type 1 and 2 diabetes [7], cancer [8], some neurological diseases [9], and the immune system diseases [10]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
