Improved fat water separation with water selective inversion pulse for inversion recovery-based cardiac MRI sequence

Lukas Havla,Hussein Rayatzadeh,Tamer A Basha,Warren J Manning,Reza Nezafat,Scott B Reeder,Jaime L Shaw,Sebastian Kozerke

doi:10.1186/1532-429x-14-s1-p276

Abstract

Background Chemical shift based water-fat separation methods can be used to reconstruct simultaneous fat and water images, thereby improving the sensitivity of fat detection using a positive fat contrast. The presence of fatty infiltration is a hallmark pathological feature of arrhythmogenic right ventricular cardiomyopathy (ARVC). Furthermore, the presence of fatty infiltration in chronic myocardial infarction has been demonstrated recently [1,2]. To assess for both presence of scar using late gadolinium enhancement (LGE) and fat, two separate scans are needed. In this study, we propose an improved inversion recovery based water-fat separation sequence in which the fat signal is retained by the application of a spectrally selective water inversion pulse, thereby eliminating the need for two separate scans.

Highlights

Chemical shift based water-fat separation methods can be used to reconstruct simultaneous fat and water images, thereby improving the sensitivity of fat detection using a positive fat contrast
A free-breathing 3D late gadolinium enhancement (LGE) sequence with multi-echo gradient echo imaging sequence and a water-selective inversion pulse was implemented on 1.5T Philips Achieva system
The fat signal is significantly decreased in images acquired with non-selective inversion; the use of a water-selective inversion retains fat signal allowing robust water-fat separation

Summary

Background

Chemical shift based water-fat separation methods can be used to reconstruct simultaneous fat and water images, thereby improving the sensitivity of fat detection using a positive fat contrast. The presence of fatty infiltration is a hallmark pathological feature of arrhythmogenic right ventricular cardiomyopathy (ARVC). The presence of fatty infiltration in chronic myocardial infarction has been demonstrated recently [1,2]. To assess for both presence of scar using late gadolinium enhancement (LGE) and fat, two separate scans are needed. We propose an improved inversion recovery based water-fat separation sequence in which the fat signal is retained by the application of a spectrally selective water inversion pulse, thereby eliminating the need for two separate scans

Methods

Results

Conclusions

Goldfarb JW