Abstract
Background and purposes: Ibuprofen is a commonly used NSAID for anti-inflammatory, antipyretic, analgesic, and antiplatelet agents. However, Ibuprofen is poorly soluble in water and its bioavailability is low. Pellets containing the solid dispersion system are considered as a drug delivery system with many outstanding advantages such as improving the stability, the solubility as well as the dissolution rate, thus increasing the bioavailability. The aim of this study was to formulate pellets containing the solid dispersion system of ibuprofen, and to evaluate the physico-chemical properties of prepared pellets. Materials and methods: Ibuprofen, PVP K30 were used in this study. Pellets were prepared by the layering technique based on the solvent method used in preparing the solid dispersion system of Ibuprofen. Results: The preparation of a solid dispersion system of ibuprofen using PVP K30 as a carrier helps to improve both the appearance and the drug solubility at the optimal drug: PVP K30 ratio of 1:10 (w/w). Pellets have a spherical shape with the size in the range of 0.7-1.0 mm, the coating efficiency of 33.27%, the drug release of pellets was 7-fold higher than that of the raw material after 60 min. Conclusions: The incorporation of Ibu-loaded solid dispersion system into pellets contributed to enhance the dissolution of Ibuprofen as compared with the raw material. Key words: Ibuprofen, pellet, solid dispersion system.
Published Version
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