Abstract
A liquid chromatographic method for the determination of the enantiomers of mefloquine has been improved. The chromatography involved two columns: an achiral cyanopropyl stationary phase for the quantification of (+/−)-mefloquine and a chiral naphthylurea stationary phase for the determination of the enantiomeric ratio. Compared with the previous method, which needed two detectors, this one used one detector—integrator to which the two columns are connected alternately by an automated column-switching system. The method is suitable for the quantification (0.05 μg/ml) of mefloquine and the determination of enantiomeric ratios from 500-μl plasma samples with ultraviolet detection.
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