Abstract
Spinal cord lesions have a real diagnostic and prognostic role in multiple sclerosis. Thus, optimizing their detection on MR imaging has become a central issue with direct therapeutic impact. In this study, we compared the 3D-MP2RAGE sequence with the conventional Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) set for cervical cord lesion detection in 28 patients with multiple sclerosis. 3D-MP2RAGE allowed better detection of cervical lesions (+62%) in this population, with better confidence, due to optimized contrast and high spatial resolution.
Highlights
Inclusion criteria were a diagnosis of MS according to the revised McDonald criteria,[2] older than 18 years of age, clinical symptoms suggesting spinal cord involvement, and MR imaging examination performed at least 3 months after steroid infusion
Ators, a senior neuroradiologist and a neurologist who were blinded to patient data, read the results of the conventional set Spinal Cord Lesions and the 3D-MP2RAGE sequence (T1 map and uniform image)
The present study reveals, for the first time in MS, that the 3DMP2RAGE method can detect cervical cord lesions with higher confidence and higher sensitivity than the recommended conventional Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) set
Summary
The aim of this study was to compare the MP2RAGE sequence with the conventional set of routine sequences for detecting spinal cord lesions in patients with MS
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