Abstract
In metazoans, the nuclear envelope (NE) breaks down (NEBD) during “open” mitosis and meiosis. In the fission yeast Schizosaccharomyces pombe, the mitosis and the first meiotic division (meiosis I) are “closed”, during which the NE is maintained. Intriguingly, during the second meiotic division (meiosis II) the NE is also maintained, but nuclear and cytoplasmic molecules are mixed similar to open mitosis, a phenomenon of unknown biological significance called “virtual” NEBD (vNEBD). Here we show that importin α-dependent nucleocytoplasmic transport regulates spindle disassembly late in anaphase B at meiosis I, as previously reported for mitosis. At meiosis II, however, spindle dissolution is triggered by vNEBD early in anaphase B, a mechanism that short-circuits the nucleocytoplasmic transport system. We demonstrate that the sequential action of these two spindle disassembly systems regulates the spatiotemporal order and ploidy of the meiotic products.
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