Abstract
Choriocarcinoma is a highly malignant trophoblastic tumor that follows normal pregnancy,abortion or ectopic pregnancy. The risk is immeasurably greater following hydatidiform mole. We present a report of a young woman who developed gestational choriocarcinoma following repeated hydatidiform mole.After thorough assessment of risk factors, combination chemotherapy in the form of MAC-FAC regimen was given for six cycles. The woman showed good compliance for two years, regarding regular follow up, treatment and contraceptive advice. Patient became pregnant after two years of follow up and gave birth to a healthy baby.
Highlights
Choriocarcinoma is a highly malignant tumor arising from the chorionic epithelium
Its important diagnostic histological feature is the absence of a villous pattern which is in contrast to hydatidiform mole or invasive mole which shows maintenance of villous pattern with formation of vesicles
Gestational Trophoblastic Neoplasia belonging to either low or high risk group is highly sensitive to chemotherapy
Summary
Choriocarcinoma is a highly malignant tumor arising from the chorionic epithelium. Approximately half of the cases follow a hydatidiform mole, 25 percent follow an abortion, and 25 percent develop after an apparently normal pregnancy. Six months after MTP, she was diagnosed as a case of hydatidiform mole at 6 weeks gestation for which she underwent dilatation and evacuation. Following evacuation, she had continuous vaginal bleeding. Histopathological report confirmed the diagnosis of hydatidiform mole When she presented to us she was confused about her pattern of bleeding and could only report that she had irregular bleeding since a period of one and half year. On examination her vital parameters were stable. Baby was devoid of any complications till six months of age
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