Abstract
The impact of manufactured nanomaterials on human health and the environment is amajor concern for commercial use of nanotechnology based products. A judicious choice ofselective usage, lower nanomaterial concentration and use in combination withconventional therapeutic materials may provide the best solution. For example,silver nanoparticles (Ag NPs) are known to be bactericidal and also cytotoxicto mammalian cells. Herein, we investigate the molecular mechanism of Ag NPmediated cytotoxicity in both cancer and non-cancer cells and find that optimumparticle concentration leads to programmed cell death in vitro. Also, the benefit ofthe cytotoxic effects of Ag NPs was tested for therapeutic use in conjunctionwith conventional gene therapy. The synergistic effect of Ag NPs on the uracilphosphoribosyltransferase expression system sensitized the cells more towards treatmentwith the drug 5-fluorouracil. Induction of the apoptotic pathway makes Ag NPs arepresentative of a new chemosensitization strategy for future application in gene therapy.
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