Abstract
Dementia, characterized by cognitive decline and memory deterioration, poses a significant and growing global health challenge. Alzheimer's disease (AD) is the most common form, with others including Lewy body dementia (LBD), frontotemporal dementia (FTD), and vascular dementia (VaD). The World Health Organization estimates that 55 million people worldwide are affected, a number projected to triple by 2050. This essay explores both non-modifiable and modifiable determinants of dementia and their implications for public health policies and prevention efforts. Non-modifiable determinants include age, genetics, and sex, all of which significantly influence dementia risk. Ageing is the primary risk factor, with genetic factors such as mutations in APP, PSEN1, and PSEN2, and the APOE 4 allele increasing susceptibility. Women, due to their longer lifespan and hormonal differences, are at a higher risk compared to men. Modifiable determinants encompass lifestyle factors and medical conditions, notably diet, physical activity, alcohol and tobacco use, hypertension, and diabetes. Effective public health policies, like the WHO's Global Action Plan, emphasize early intervention and lifestyle modifications. Integrating these determinants into policy making requires a balanced approach, considering the dynamic nature of modifiable factors and the specific needs of an aging population. The essay underscores the need for comprehensive public health education, destigmatization of dementia, and an inclusive healthcare infrastructure to enhance dementia prevention and care, ultimately reducing the societal burden of this condition.
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