Abstract
BackgroundC1q/TNF-related protein-3 (CTRP-3), an adiponectin paralog, and progranulin were recently identified as novel adipokines which may link obesity with glucose dysregulation and subclinical inflammation. We analyzed the relationship between CTRP-3, progranulin and coronary artery disease (CAD) in Korean men and women.MethodsCirculating CTRP-3 and progranulin levels were examined in 362 Korean adults with acute coronary syndrome (ACS, n = 69), stable angina pectoris (SAP, n = 85), and control subjects (n = 208) along with various kinds of cardiometabolic risk factors.ResultsCTRP-3 concentrations were significantly decreased in patients with ACS or SAP compared to control subjects (P <0.001, respectively), whereas progranulin and adiponectin levels were similar. Correlation analysis adjusted for age and gender exhibited that CTRP-3 levels showed significant negative relationship with glucose (r = -0.110, P = 0.041) and high sensitive C-reactive protein (hsCRP) levels (r = -0.159, P = 0.005), and positive relationship with HDL-cholesterol (r = 0.122, P = 0.025) and adiponectin levels (r = 0.194, P <0.001). In a multivariate logistic regression analysis, the odds ratio for CAD risk was 5.14 (95% CI, 1.83-14.42) in the second, and 9.04 (95% CI, 2.81-29.14) in the first tertile of CTRP-3 levels compared to third tertile after adjusting for other cardiometabolic risk variables.ConclusionsPatients with ACS or SAP had significantly lower circulating CTRP-3 concentrations compared to control subjects, although progranulin levels were not different. These results suggest the possibility that CTRP-3 might be useful for assessing the risk of CAD.Trial registration(Clinical trials No.: NCT01594710)
Highlights
C1q/TNF-related protein-3 (CTRP-3), an adiponectin paralog, and progranulin were recently identified as novel adipokines which may link obesity with glucose dysregulation and subclinical inflammation
Using a recently developed enzymelinked immunosorbent assay (ELISA), we reported that circulating C1q/TNFrelated protein (CTRP)-3 levels were elevated in patients with glucose metabolism dysregulation [10]
CTRP-3 concentrations were significantly decreased in patients with Acute coronary syndrome (ACS) or stable angina pectoris (SAP) compared to control subjects (P
Summary
C1q/TNF-related protein-3 (CTRP-3), an adiponectin paralog, and progranulin were recently identified as novel adipokines which may link obesity with glucose dysregulation and subclinical inflammation. Adiponectin is the insulin-sensitizing adipokine with anti-inflammatory and Recently, a new family of secreted proteins, C1q/TNFrelated protein (CTRP), was cloned on the basis of sequence homology with adiponectin [4]. This family of adiponectin paralogs might have pivotal implications in energy homeostasis and obesity-related inflammation [5]. Using a recently developed enzymelinked immunosorbent assay (ELISA), we reported that circulating CTRP-3 levels were elevated in patients with glucose metabolism dysregulation [10]. Yi et al revealed that CTRP-3 is a novel antiapoptotic, proangiogenic and cardioprotective adipokine, the expression of which is significantly inhibited after MI [14]
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