Abstract

Aims: We assessed the implementation and effectiveness of an updated protocol designed to improve pain management in cardiac surgery patients. The new updated protocol was recommended systemic pain assessment every four hours unless patients were unstable, using the numerical rating score (NRS) after the endotracheal extubation. Our secondary aim was to analyze the factors predicting patients’ postoperative pain to guide development of future pain management protocols. Methods: Fifty patients undergoing cardiac surgery with median sternotomy were evaluated in this audit. Perioperative details and details regarding analgesic administration were collected. High-risk patients were classified as ones with a history of substance misuse, chronic pain, and preoperative opioid use. Pain was measured at rest, on coughing and on moving, for the first three postoperative days (POD), using 11-point NRS (0–10). Pain was considered “unacceptable” if it was NRS ≥4 at rest, and NRS ≥8 on activity. A univariate and multivariate mixed model linear regression was used to investigate factors that may contribute to pain following cardiac surgery. Results: On POD1 38% of patients reported unacceptable pain at rest, and 27% reported unacceptable pain on coughing or moving. There was limited implementation of the new protocol, thus we cannot comment on the effectiveness of the updated protocol. Multivariate analysis demonstrated an overall significant interaction effect between postoperative day and risk (p = 0.032). It was found that high-risk patients reported pain to be greater than pain reported by low-risk patients on POD3 (2.14, CI −0.32 to 4.26, p = 0.054). Use of preoperative gabapentin did not affect pain at rest nor pain on coughing or moving (p > 0.5). Conclusion: The new pain protocol was not followed in the majority of patient cases. Preoperatively, only 25 (56%) patients received gabapentin. No patients received patient-controlled analgesia (PCA) postoperatively. Seven (15%) patients identified as high risk received no differential pharmacological management contrary to the updated protocol. It is believed that e-mail is not sufficient to implement a new protocol such as this, thus resulting in protocol implementation failure. However, it was found that postoperative pain differed between high-and low-risk patients, especially at rest. This indicates that risk assessment and individualized pain protocols are important to optimize postoperative pain management following cardiac surgery. We have discussed the efforts required to improve future protocol implementation and pain management across disciplines.

Highlights

  • This document aims to identify elements of good practice in the management of pain and in the prescription of opioid drugs

  • The primary purpose of prescribing opioids is for pain relief but complete relief of symptoms is rarely achievable: an acceptable balance between useful reduction in pain intensity and side effects is the goal

  • Both International Classification of Diseases, Tenth Revision (ICD-10) and DSM-IV definitions have diagnostic criteria based on these elements as well as inclusion of an item on continued substance use in the face of harm caused by its use

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Summary

Introduction

This document aims to identify elements of good practice in the management of pain and in the prescription of opioid drugs It provides non-specialists with appropriate information to assess the needs of and manage pain in patients who are or have previously been substance misusers. The document considers the epidemiology of pain and of substance misuse, relevant neurobiology and pharmacology as well as definitions, legal requirements and therapeutic interventions to inform clinicians and improve practice. The document is accompanied by an information leaflet supporting patients at risk of substance misuse in making informed treatment choices about pain management It helps them and their carers recognise problems that may occur and explains what sort of information needs to be given to professionals from whom they are seeking help, to support a safe and effective management plan

Methods
Executive Summary
Epidemiology of pain and of substance misuse
Neurobiology of pain
Neurobiology of addiction
Substance misuse: terminology
Pharmacology of substance misuse
Pharmacology of specific drugs
Pharmacological treatment of addicition Note
Important drug interactions
Section 2: Drugs and the Law
A Controlled Drug prescription must not be supplied by any person:
Non-Medical Prescribing – Current Position on Controlled Drugs
The Shipman Inquiry - Implications for controlled drug prescribing
Key principles
Opioids in the management of persistent pain: general considerations
Opioid therapy: potential problems
Problem drug use when prescribing controlled drugs for pain
Current good practice in addiction medicine
Assessment
Patient needs
General guidance
Patients recovering from addiction
Common clinical scenarios
General Practice and Pain Management Services
Liaison with Specialist Addiction Services
Acute pain management
Palliative care
Pain relief in labour
Findings
Background
Full Text
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