Abstract
A series of complex logic gates were constructed based on graphene oxide and DNA-templated silver nanoclusters to perform both arithmetic and nonarithmetic functions. For the purpose of satisfying the requirements of progressive computational complexity and cost-effectiveness, a label-free and universal platform was developed by integration of various functions, including half adder, half subtractor, multiplexer and demultiplexer. The label-free system avoided laborious modification of biomolecules. The designed DNA-based logic gates can be implemented with readout of near-infrared fluorescence, and exhibit great potential applications in the field of bioimaging as well as disease diagnosis.
Highlights
Graphene oxide (GO) and water-soluble carbon materials have been deeply and intensively investigated in various fields[24]
The near-infrared-emitting AgNCs were stabilized by the single-stranded DNA, which was used as the template (Ag-DNA) in the present system
GO is capable of differentiating single-stranded DNA (ss-DNA) from double-stranded DNA and the G-quadruplex
Summary
Graphene oxide (GO) and water-soluble carbon materials have been deeply and intensively investigated in various fields[24]. Willner’s group has demonstrated that the GO can quench the fluorescence of AgNCs25. Based on this theory, a series of logic functions have been achieved by Dong et al.[19]. We proposed a label-free platform based on GO and DNA-template AgNCs to avoid the DNA modification. The proposed platform should have the ability to perform multicomponent functions in order to solve the computational complexity. A series of complex logic gates were constructed based on the same platform and a constant threshold setpoint to perform different type functions, including arithmetic (half adder and half substractor) and nonarithmetic (multiplexer and demultiplexer) functions. It’s worth noting that the constructed logic circuits can be implemented with output of near-infrared fluorescence and in enzyme-free condition, having a prospective application on bio-imaging and disease diagnosis and therapy[26,27]
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