Implementation of a Deep Learning Algorithm Based on Vertical Ground Reaction Force Time-Frequency Features for the Detection and Severity Classification of Parkinson's Disease.

Abstract

Conventional approaches to diagnosing Parkinson’s disease (PD) and rating its severity level are based on medical specialists’ clinical assessment of symptoms, which are subjective and can be inaccurate. These techniques are not very reliable, particularly in the early stages of the disease. A novel detection and severity classification algorithm using deep learning approaches was developed in this research to classify the PD severity level based on vertical ground reaction force (vGRF) signals. Different variations in force patterns generated by the irregularity in vGRF signals due to the gait abnormalities of PD patients can indicate their severity. The main purpose of this research is to aid physicians in detecting early stages of PD, planning efficient treatment, and monitoring disease progression. The detection algorithm comprises preprocessing, feature transformation, and classification processes. In preprocessing, the vGRF signal is divided into 10, 15, and 30 s successive time windows. In the feature transformation process, the time domain vGRF signal in windows with varying time lengths is modified into a time–frequency spectrogram using a continuous wavelet transform (CWT). Then, principal component analysis (PCA) is used for feature enhancement. Finally, different types of convolutional neural networks (CNNs) are employed as deep learning classifiers for classification. The algorithm performance was evaluated using k-fold cross-validation (kfoldCV). The best average accuracy of the proposed detection algorithm in classifying the PD severity stage classification was 96.52% using ResNet-50 with vGRF data from the PhysioNet database. The proposed detection algorithm can effectively differentiate gait patterns based on time–frequency spectrograms of vGRF signals associated with different PD severity levels.