Abstract
Background:Aminoglycosides are commonly used in the treatment of infective endocarditis (IE). Because of it′s nephrotoxic potential it′s place in the treatment arsenal is currently being debated.What is the potential risk of giving short-term therapy ( 2500mg tobramycin implicated a decreased reversibility of eGFR during 1-year F/U. Concomitant vancomycin + tobramycin therapy caused a 19% loss in eGFR while no reduction followed sequential vancomycin + tobramycin therapy. Patients with an initial eGFR 2500mg tobramycin therapy caused a decreased reversibility during 1-year F/U, while short-term therapy<10 days had no impact on long-term kidney function.
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