Abstract
The effect of ventilating individual lungs with different levels of oxygen and humidity, as measured by blood Po2 levels, was studied in dogs ventilated with a tracheal divider. One of the isolated lungs served as a control for the other. Humidity of the gases ranged from dry to 50 mg. of water per liter. After prolonged ventilation, the lung ventilated with the high oxygen mixtures produced gradually decreasing Po2 values. The diminution in oxygenation measured after prolonged ventilation with high concentrations of oxygen was most severe when the oxygen used was dry or else humidified at levels corresponding to that produced by a commonly used clinical apparatus. Oxygenation was best preserved when humidification was maintained at substantially lower optimum levels.
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