Impacts of detrusor overactivity on patients with benign prostate hyperplasia

Abstract

Objective To elucidate if detrusor overactivity(DO)has influence on patients with benign prostate hyperplasia.Methods Forty-seven patients who were suspected to suffered from BPH were divided into two groups according to whether have DO in pre-operative urodynamic analysis.There were 22 patients in DO group and 25 in non-DO group.All patients received transurethral resection of prostate (TURP).Pre-operative variables such as relevant clinical data,International Prostate Symptom Score (IPSS),quality of life (QOL) index,maximum urine flow rate(Q~(max)) and pressure-flow study data were recorded.Patients were monitored after operation and the corresponding data were recorded.Results Prostate size in DO group was (77±25)ml,and in non-DO group was (56±27) ml,P=0.02;first desire bladder volume in DO group was (104±36) ml,and in non-DO group was (161±54) ml,P=0.001;urgent desire bladder volume in DO group was (245±73) ml,and in non-DO group was (328±94)ml,P=0.006;pre-operative residual urine in DO group was (71±49)ml,and in non-DO group was (149±125)ml,P=0.015;linPURR obstruction grade in DO group was 4.63±0.95,and in non-DO group was 3.35±1.90,P=0.014.The IPSS and QOL before and after operation had no significant differences between the 2 groups.Conclusions The patients with larger prostates and more severe bladder outlet obstruction are more likely to have DO.Patients with DO had smaller bladder volume and residual urine volume before operation.DO has no significant effect on BPH patient's IPSS and QOL. Key words: Urinary bladder,overactive; Prostaic hyperplasia; Quality of life