Abstract
BackgroundWith the advancement of next generation sequencing technology, researchers are now able to identify important variants and structural changes in DNA and RNA in cancer patient samples. With this information, we can now correlate specific variants and/or structural changes with actionable therapeutics known to inhibit these variants. We introduce the creation of the IMPACT Web Portal, a new online resource that connects molecular profiles of tumors to approved drugs, investigational therapeutics and pharmacogenetics associated drugs.ResultsIMPACT Web Portal contains a total of 776 drugs connected to 1326 target genes and 435 target variants, fusion, and copy number alterations. The online IMPACT Web Portal allows users to search for various genetic alterations and connects them to three levels of actionable therapeutics. The results are categorized into 3 levels: Level 1 contains approved drugs separated into two groups; Level 1A contains approved drugs with variant specific information while Level 1B contains approved drugs with gene level information. Level 2 contains drugs currently in oncology clinical trials. Level 3 provides pharmacogenetic associations between approved drugs and genes.ConclusionIMPACT Web Portal allows for sequencing data to be linked to actionable therapeutics for translational and drug repurposing research. The IMPACT Web Portal online resource allows users to query genes and variants to approved and investigational drugs. We envision that this resource will be a valuable database for personalized medicine and drug repurposing. IMPACT Web Portal is freely available for non-commercial use at http://tanlab.ucdenver.edu/IMPACT.
Highlights
With the advancement of generation sequencing technology, researchers are able to identify important variants and structural changes in DNA and RNA in cancer patient samples
Integrating Molecular Profiles with Actionable Therapeutics (IMPACT) Web Portal allows for sequencing data to be linked to actionable therapeutics for translational and drug repurposing research
We present IMPACT Web Portal, a database linking the molecular profiles of tumors to clinical and pre-clinical oncology actionable therapeutics
Summary
With the advancement of generation sequencing technology, researchers are able to identify important variants and structural changes in DNA and RNA in cancer patient samples With this information, we can correlate specific variants and/or structural changes with actionable therapeutics known to inhibit these variants. Generation sequencing of cancer genomes has revolutionized the field of precision oncology in recent years Using this technology, it is possible to classify cancer subtypes based on the similarity of their molecular profiles. We previously published a whole exome sequencing (WES) analysis pipeline, IMPACT (Integrating Molecular Profiles with ACtionable Therapeutics) that matches molecular profiles with actionable therapeutics [2]. This tool is currently only available for WES data and requires command line-level programming
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