Abstract
and 3000 IU of vitamin D per day. Maintenance therapy includes 2000 IU of vitamin D per day. The aim of study was to assess the efficacy and safety of individual targeted vitamin D therapy in postmenopausal women with primary osteoarthritis. The study involved 40postmenopausalwomenaged46–87 years. All subjects were subdivided into two groups:main – 20womenwho took individual targeted vitaminD therapy (20 subjects, 65.1±8.8 years old, BMI 27.22±4.51kg/m2) and control (20 subjects, 64.5±11.1 years old, BMI26.68±4.95kg/m2). Thedurationof the treatment consists of 3 mos. 25(OH)D total and iPTH levels were assessed by electrochemiluminescent method using Elecsys 2010 analytical system (Roche Diagnostics, Germany) and test-systems cobas. The serum levels of calcium, phosphor, alkaline phosphatase levels were evaluated for safety reasons. In 3 mos after the start of the treatment there was a significant (p 70 yrs.), as well as in subjects with the BMI 25–28.99kg/m2. Themajor finding of the present study is that the individual targeted vitamin D therapy was proven to be effective in postmenopausal womenwith primary osteoarthritis. As the treatment turned out to be effective, relatively quick, and had a reasonable safety profile.
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