Abstract
Background Autism Spectrum Disorder (ASD) is a developmental disorder that affects the behavior and social communication of the child. In India, awareness about Autism coupled with shortage of skilled professionals poses severe constraints in management of children with ASD. There arises a need to explore the avenues of alternate therapy in the form of Group Therapy. A 44-bp insertion/deletion polymorphism in the promoter region of the serotonin receptor gene 5-HTT gene (5-HTTLPR) has been identified to modify the transcription rate of the gene (Lesch et al., 1996; Greenberg et al., 1999). The short allelic variant has been shown to reduce 5-HTT transcription resulting in diminished 5-HTT levels and reduced serotonin (5-HTT) reuptake into human platelets. We speculate the possibility of altered hormone levels (Melatonin and Serotonin) in individuals with ASD. As per earlier reports an association between 5-HTT gene polymorphism and autism has been indicated. Recent evidences from clinical and neuroscience research suggests an approach based on yogic principles and meditative tools is worth experimenting in children with autism. The same could be addressed in ASD individuals to ameliorate the drastic effect of these hormones on ASD individuals.
Highlights
Autism Spectrum Disorder (ASD) is a developmental disorder that affects the behavior and social communication of the child
In India, awareness about Autism coupled with shortage of skilled professionals poses severe constraints in management of children with ASD
The short allelic variant has been shown to reduce 5-HTT transcription resulting in diminished 5-HTT levels and reduced serotonin (5-HTT) reuptake into human platelets
Summary
Autism Spectrum Disorder (ASD) is a developmental disorder that affects the behavior and social communication of the child. In India, awareness about Autism coupled with shortage of skilled professionals poses severe constraints in management of children with ASD. There arises a need to explore the avenues of alternate therapy in the form of Group Therapy. A 44-bp insertion/deletion polymorphism in the promoter region of the serotonin receptor gene 5-HTT gene (5-HTTLPR) has been identified to modify the transcription rate of the gene (Lesch et al, 1996; Greenberg et al, 1999). The short allelic variant has been shown to reduce 5-HTT transcription resulting in diminished 5-HTT levels and reduced serotonin (5-HTT) reuptake into human platelets. We speculate the possibility of altered hormone levels (Melatonin and Serotonin) in individuals with ASD
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