Impact of type-2 diabetes mellitus on expression of atp-sensitive potassium channel subunits in human bypass grafts

Abstract

Background and Aims : Prevalence of type-2 diabetes mellitus (T2DM) among patients that require coronary artery bypass graft (CABG) surgery increased over the years. It is well knowing that diabetes has impact on endothelial function and that cause impaired vasodilation function of blood vessels. However, vasorelaxation can be, also, achieved through opening of potassium (K) channels on vascular smooth muscle. Thus, the aim of our study was to detect the differences in the expression of ATP-sensitive K (KATP) channel subunits in bypass grafts (saphenous vein, SV and internal mammary artery, IMA) obtained from patients with and without T2DM.