Abstract
Purpose: Even though Osteoarthritis (OA) is the most common joint disorder and the leading cause of disability and chronic pain in the elderly with a major socio-economic impact, research efforts have not yet been able to define its exact etiology. Beside loss of function, pain is the main clinical feature that leads to intervention, including non-pharmacological, pharmacological, and surgical approaches. The joints are innervated by calcitonin gene-related peptide (αCGRP)- and substance P (SP)- positive sensory nerve fibers, which are a potential source of tibial-femoral pain during OA pathogenesis.
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