Abstract
A multi-parametric assessment of the impact of storage time/conditions and capping agent charge on the stability and toxicity of AgNPs showed agglomeration, dissolution, oxidation, capping agent degradation and attachment of Ag+ions all play a role.
Highlights
Nanoparticles (NPs) possess outstanding properties, which make them applicable in many areas of our daily life
We found that both storage time/ conditions and surface chemistry of AgNPs influenced the evolution of the NP properties over time, and that the resulting changes in the NPs' physicochemical properties influenced their toxicity
The present study aims to contribute to this effort by investigating one speci c topic, particle aging, in the case of AgNPs as a function of storage conditions and capping agent composition and charge
Summary
Nanoparticles (NPs) possess outstanding properties, which make them applicable in many areas of our daily life. Many studies evaluating the toxicity of AgNPs in vitro and in vivo have been published, the conclusions are inconsistent and it is not yet entirely clear whether the toxicity is primarily related to dissolved ionic forms of silver (Ag+) or results from the NP forms (Ag0 NPs).[9,10,11] This can be correlated with a lack of sufficient characterization of the materials being studied, including their speciation between Ag+ ions and Ag0 NPs and other insoluble forms, especially at the time of toxicological evaluation
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