Abstract
Introduction: Hypertriglyceridemia is an established risk factor for acute pancreatitis. This study seeks to evaluate the effect of serum triglycerides on the development of persistent or multiple organ failure in patients with acute pancreatitis. Methods: A retrospective cohort study was conducted using data from an integrated healthcare system. Patients hospitalized for acute pancreatitis between January 1, 2006 and December 31, 2013 were included in the study. Triglyceride levels measured prior to and within 72 hours of admission were compared. In addition, the impact of serum triglycerides on the development of persistent or multiple organ failure during hospitalization for acute pancreatitis was assessed using Poisson regression models adjusting for age and sex. Results: Among 2,519 patients, 267 patients (10.6%) developed organ failure, of which 75 patients (28.1%) developed multiple system organ failure and 82 patients (30.7%) developed persistent organ failure. Serum triglyceride levels in patients who developed organ failure were initially much higher than in patients who did not develop organ failure, but by 72 hours into the admission, approached levels of the patients who did not develop organ failure. Approximately 7% of patients had very high serum triglyceride levels (>500 mg/dL), which correlated with similarly high triglycerides levels prior to admission. Conclusion: Increased TG levels were associated with the development of multiple or persistent organ failure in this study of patients hospitalized with acute pancreatitis. Patients with high triglyceride levels at the time of admission for acute pancreatitis were likely to have high triglyceride levels prior to admission.
Published Version
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