Abstract

Impact of Routine Varicella Immunization on Varicella Ambulatory Visits in a Tertiary Hospital in Athens, Greece

Highlights

  • Varicella is a highly contagious disease caused by primary infection with the varicella zoster virus (VZV), characterized by a benign self-limiting clinical course [1]

  • Interrupted time series analysis showed that introduction of varicella vaccination in 2004 had a significant effect of on varicella incidence

  • Our model predicted a significant decrease in varicella incidence in the first year (2004) of the intervention (-55.36, 95%CI= -95.58, -15.13, p

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Summary

Introduction

Varicella is a highly contagious disease caused by primary infection with the varicella zoster virus (VZV), characterized by a benign self-limiting clinical course [1]. Following primary infection, VZV becomes latent in the dorsal root ganglia and may reactivate later in life causing herpes zoster (HZ), a localized painful rash often associated with severe morbidity. As the disease burden of VZV is notable, routine immunization against varicella has been implemented in several countries and resulted in a significant decrease of varicella infection rates [2]. In the USA where routine vaccination has been implemented since 1995, significant decreases in the incidence rate and attributable mortality of varicella, as well as in varicella-related hospitalizations, have been documented [2,3,4].

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