Abstract
Cannabis sativa is an illicit drug with proven anti-inflammatory, analgesic, antipyretic and anti diarrhea activities. This present study is aimed at ascertaining the impact of Cannabis sativa on some biochemical indices of albino rats. Twenty (20) male wistar albino rats ranging from180-200g were acclimated to laboratory conditions for 7days, following which they were randomly assigned into 4 groups i, ii, iii and iv of five animals each based on average body weight. Groups (ii-iv) were administered 0.5 ml aqueous extract of Cannabis sativa via oral route corresponding to 1, 2 and 3mg/Kg/body weight, while group i (control) received 0.5ml of distilled water orally. Rats in all groups were sacrificed 24hours after the experimental periods of 30daysoforaladministration of the extract. The extract significantly (p<0.05) increased serum Albumin, Globuli n, Total protein, Conjugated bilirubin while Total bilirubin, unconjugated bilirubin concentration showed a significant (p<0.05) increase only in group ii and iv when compared with the control. Likewise group ii and iii showed a significant (p<0.05) reduction in total cholesterol .The serum AST and ALT showed a significant (p<0.05) increase when compared with the control. The alterations by the results are manifestation of mild hepatorenal toxicity and anti-hypercholesterolemic effect.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
