Abstract
The present investigation was designed to evaluate the effect of two oral administered antibiotics (Rifampicin and Tetracycline) on some physiological parameters in the serum of male albino rats. Histopathological alterations in liver and kidney were also examined. Data showed that treatment of rats with rifampicin caused a significant increase in the total cholesterol, triglycerides and LDL-cholesterol levels, while HDL-cholesterol level showed a significant decrease. Moreover, significant increases in serum AST, ALT, bilirubin and urea were observed. Also, the levels of the total protein, albumin and alpha 1-globulin were significantly decreased. No significant changes were recorded in the rest of the globulin fractions (alpha 2-, beta- and gamma-globulin) and albumin/globulin ratio (A/G) as well as creatinine level.In the serum of tetracycline-treated rats, the triglycerides, LDL-cholesterol, AST, ALT, bilirubin, urea, creatinine and gamma-globulin levels increased significantly. On the other hand, HDL-cholesterol, total protein, albumin levels and A/G ratio showed significant decreases. No significant changes in the total cholesterol, alpha 2- and beta-globulin levels were detected.Histological examination of the liver and kidney in the rifampicin-treated rats indicated that the liver pathology includes necrosis of hepatocytes, cytoplasmic vacuolation, and distended sinusoids with some lymphatic aggregations. In the kidney, the glomeruli increased in size, the mesangial matrix was expanded and the renal tubules were degenerated. Histological analysis of liver samples of tetracycline – treated rats revealed high vacuolation of the cytoplasm of hepatic cells, sinusoidal dilation, hepatocellular necrosis and disappearance of the cell membrane in some hepatocytes. The kidney sections of rats treated with tetracycline showed shrinkage of the glomeruli, widening of the Bowman’s space, in addition to necrosis and vacuolation of the renal tubules.
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