Impact of RAAS, NT-proBNP, inflammatory factors and clinical efficacy in chronic heart failure(CHF) patients with Qi deficiency type treated by Buzhong-Yiqi decoction

Abstract

Objective To research the impact of renin-angiotensin-aldosterone system (RAAS), NT-proBNP, inflammatory factors and clinical efficacy in chronic heart failure (CHF) patients with Qi deficiency type treated by Buzhong-Yiqi decoction, in order to discuss the mechanism of action. Methods A total of 240 CHF patients with Qi deficiency type were divided into observation group and control group according to random number table in our hospital during 2013.6-2016.6, 120 patients in each group. The patients were given conventional western medicine treatment in control group, and the patients were added Buzhong-Yiqi decoction in observation group basesd on the control group. All the patients were continuously treated for 4 weeks. The Qi deficiency type TCM symptoms scores were evaluated before and after treatment. The serum level of renin (REN), angiotensinⅡ (AngⅡ), aldosterone (ALD) were detected by electrochemiluminescence. The serum level of N-terminal pro-brain natriuretic peptide (NT-proBNP), hs-CRP, TNF-α, IL-6 was detected by enzyme linked immunosorbent assay. The cardiac index (CI), stroke index (SI), ejection fraction (EF) was measureed by ultrasonic cardiogram. The clinical efficacy was evaluated. Results After treatment, the total effective rate was 70.0% (84/120) in observation group and 55.0% (66/120) in control group, and there was statistical significance between two groups (χ2=6.153, P<0.05). The CI, SI, EF of observation group was significantly higher than those of control group (t=3.328, 4.524, 3.416, all P<0.01). The serum of REN, AngⅡ, ALD, NT-proBNP of observation group were significantly lower than those of control group (t=2.630, 6.122, 4.106, 5.261, all P<0.01). The serum of hs-CRP, TNF-α, IL-6 of observation group was significantly lower than those of control group (t=3.879, 11.625, 7.673, all P<0.01). The TCM symptoms scores of observation group was significantly lower than that of control group (t=6.117, P<0.01). Conclusions The clinical efficacy was significant on Qi deficiency type CHF patients treated by Buzhong-Yiqi decoction and it could effectively inhibit the RAAS, NT-proBN, inflammatory factors. Key words: Bu Zhong Yi Qi Tang; Heart failure; Qi deficiency; Renin-angiotensin system; N-terminal pro-brain natriuretic peptide