IMPACT OF POLYCYCLIC AROMATIC HYDROCARBONS ON MALE REPRODUCTIVE HEALTH IN COAL TAR WORKERS

Abstract

Introduction: It’s well known that exposure to polycyclic aromatic hydrocarbons (PAHs) increasesthe risk of cancer; however less is known about their adverse effects on male reproductive health. Aim of work: To assess the effects of occupational exposure to PAHs on male reproductive health in a company for coke production. Materials and methods: A cross sectional comparative study was performed on an exposed group of coal tar workers (No=45) and a matched control group (No=45). Personal interview with specially designed questionnaire and standardized self-completed questionnaire was done to assess the erectile dysfunction. Urinary 1-hydroxypyrene (1-OH Pyrene) and serum malondialdehyde (MDA) in addition to reproductive hormones and semen analysis were assessed. Results: The study revealed a statistically significant increase in the level of 1-OHpyrene,MDA and estradiol ratio among the exposed group with Mean ±SD 8.42±3.61, 11.95±7.29, 7.89±3.45 vs 3.14±3.51, 2.44±1.61, 6.59±2.21 respectively among the controls with p 0.05). Conclusion and recommendations: The adversehealth effect on the male reproductive system in the current study might be one of the hazards that can be attributed to occupational exposure to PAHs in coal tar workers. Regular wearing of good quality personal protective equipment, especially masks and gloves is highly recommended to decreaseexposure to PAH in addition to screening with urinary 1-OH pyrene and serum MDA levels.