Impact of numerical variation, allele burden and mutation length on outcomes in acute myeloid leukemia with fms-like tyrosine kinase receptor-3 internal tandem duplication (FLT3-ITD) mutation.

Ahmad Ghorab,Farhad Ravandi,Gautam Borthakur,Tapan M Kadia,Hagop M Kantarjian,Naveen Pemmaraju,Dai Chihara,Jorge E Cortés ,A W Price ,Naval Daver ,Courtney D Dinardo ,Keyur P Patel

doi:10.1200/jco.2018.36.15_suppl.7023

Impact of numerical variation, allele burden and mutation length on outcomes in acute myeloid leukemia with fms-like tyrosine kinase receptor-3 internal tandem duplication (FLT3-ITD) mutation.

Ahmad Ghorab, Farhad Ravandi + Show 10 more

https://doi.org/10.1200/jco.2018.36.15_suppl.7023

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Journal: Journal of Clinical Oncology

Publication Date: May 20, 2018

Affiliation: The University of Texas MD Anderson Cancer Center

#High Allelic Burden #Allele Burden #Acute Myeloid Leukemia #Insert Size #Internal Tandem Duplication Mutation #Tandem Duplication Mutation #Adverse Outcomes #Duplication Mutation #High Burden #Fms-like Tyrosine Kinase Receptor-3

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7023Background: While high allelic burden is known to be associated with adverse outcomes in FLT3-ITD mutated AML, the impact of numerical variation and insert size on clinical outcome of AML patie...

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Impact of numerical variation, allele burden and mutation length on outcomes in acute myeloid leukemia with fms-like tyrosine kinase receptor-3 internal tandem duplication (FLT3-ITD) mutation.