Abstract
Recently some plasma biomarkers of inflammation have been recognized as important cardiovascular risk factors. There is little information about the effects of aerobic exercise training on these biomarkers and the risk of metabolic complications in obese type 2 diabetes patients. To compare the impact of moderate versus mild aerobic exercise training on the inflammatory cytokines in obese type 2 diabetic patients. Fifty obese type 2 diabetic patients of both sexes with body mass index (BMI) varying from 31 to 36 kg/m(2), non smokers, free from respiratory, kidney, liver, metabolic and neurological disorders, participated in this study. Their age ranged from 40 to 55 years. The subjects were included into two equal groups; the first group (A) received moderate aerobic exercise training. The second group (B) received mild aerobic exercise training, three times / week for 3 months. The mean values of leptin, TNF- alpha, IL2, IL4, IL6, HOMA-IR and HBA1c were significantly decreased in group (A) and group (B). Also, there were significant differences between both groups after treatment. Moderate aerobic exercise training modulates inflammatory cytokines more than mild aerobic exercise training in obese type 2 diabetic patients.
Highlights
Type 2 diabetes is one of the fastest growing public health problems
Morbidity and mortality in type 2 diabetes is mainly associated with atherosclerotic cardiovascular disease and late complications as a result of dysfunction of plasma biomarkers of inflammation including leptin, tumor necrosis factor- alpha (TNF- alpha) and interleukin-6 (IL-6)
The mean values of leptin, TNF-alpha, C- reactive protein (CRP), IL-2, IL-4, IL-6, Homeostasis Model Assessment-Insulin Resistance (HOMA)-IR and HBA1c were significantly decreased in group (A) and group (B)
Summary
Type 2 diabetes is one of the fastest growing public health problems. Cardiovascular disease (CVD), the number one cause of mortality in the USA, is almost twice as common as in individuals with diabetes[1]. Morbidity and mortality in type 2 diabetes is mainly associated with atherosclerotic cardiovascular disease and late complications as a result of dysfunction of plasma biomarkers of inflammation including leptin, tumor necrosis factor- alpha (TNF- alpha) and interleukin-6 (IL-6). These factors have paracrine/ autocrine functions that include regulation of energy expenditure, in part, by modulating whole-body insulin sensitivity[2]. Methods: Fifty obese type 2 diabetic patients of both sexes with body mass index (BMI) varying from 31 to 36 kg/m2, non smokers, free from respiratory, kidney, liver, metabolic and neurological disorders, participated in this study.
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