Abstract
To improve cardiovascular health, the WHO recommends 60 minutes of frequent moderate intensity physical activity in childhood. ACSM also recommends physical activity 30 minutes moderate activity or 30 minutes vigorous intensity, 3-4 times per week. However, limited data concerned in exercise starting from childhood effect to oxidative stress marker in vascular. Therefore the long-term effects of moderate intensity aerobic exercise training in early age on the cardiovascular, specifically on vascular stress oxidative marker needed to be studied. This study was conducted on male Wistar rats aged 3 weeks (60-70 grams), randomly allocated into 2 groups: 1) control group and 2) training group. Aerobic exercise training was conducted for 8 weeks on treadmill with age-dependent speeds. Training was intermittently 5 days each week for 20 minutes. Vascular oxidative stress marker was analyzed by measuring the level of malondialdehyde (MDA) and superoxide dismutase (SOD) activity on the abdominal aorta. Both the levels of MDA and SOD activity tended to increase in training group compared to the control group. The resuls of this study showed that long-term effects of moderate intensity aerobic exercise training in juvenile tended to increase the levels of MDA and specific SOD activity in the abdominal aorta tissues.
Highlights
Cardiovascular diseases may have their origins in the early childhood [1,2]
All of risk factor of cardiovascular diseases are related with increased radical oxygen species (ROS) production in the vascular wall [3]
Sufficient ROS concentration play a number of regulatory function in normal condition, but increased ROS production can cause various cardiovascular diseases [3,4]
Summary
Cardiovascular diseases may have their origins in the early childhood [1,2]. All of risk factor of cardiovascular diseases are related with increased radical oxygen species (ROS) production in the vascular wall [3]. Sufficient ROS concentration play a number of regulatory function in normal condition, but increased ROS production can cause various cardiovascular diseases [3,4]. ROS play an important role in vascular homeostasis in physiological condition. ROS can produced by NADPH oxidase, xanthine oxidase, uncoupling eNOS, mitochondrial respiration [3,5], myeloperoxidase, lypoxogenases, and transition metal [5]. Increased ROS in vascular wall can activate transcription of pro-inflammatory genes, endothelial cells, and leukocyte cells, that leading to atherosclerosis [3]
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