Impact of missense mutation (rs1990760) at interferon-induced helicase (1) gene on non-segmental vitiligo

Abstract

ObjectiveTo investigate the role of IFIH1 gene polymorphism C/T (rs1990760) in non-segmental vitiligo and to correlate the results with the available clinical data. Patients and methodsA case-control study was conducted on a total number of 100 subjects and categorized into: 50 patients with non-segmental vitiligo and 50 age and gender matched healthy volunteers. Patients were recruited from the Dermatology Outpatient Clinic, Menoufia University hospitals. Control subjects were selected from the blood bank attendants Menoufia University Hospital. Every patient was subjected to history taking, complete general examination, detailed dermatological examination with determination of site and number of lesions, assessment of severity of vitiligo and assessment of disease activity. Results14 (28%) cases were with generalized vitiligo, 13 (26%) cases had acrofacial vitiligo, 12 (24%) cases were with focal vitiligo and 11 (22%) cases were with universal vitiligo. VASI score ranged from 3 to 50 with mean 16.78 ± 10.545 and VIDA score ranged from −1–4 with mean 2.08 ± 1.576. There was statistically highly significant difference between cases and controls regarding IFIH1 genotypes (P < 0.001), IFIH1 alleles (P < 0.001). TT genotype and T allele were significantly more frequent in non-segmental vitiligo patients when compared to healthy controls. There was statistically significant relationship between IFIH1 genotypes and onset of the disease, mucosal affection and type of non-segmental vitiligo (P = 0.005, 0.001, <0.001 respectively). There was statistically highly significant positive correlation between VASI score and duration of the disease in years (P < 0.001). ConclusionIFIH1 could be considered as a good candidate gene for vitiligo susceptibility.