Impact of MELD allocation system on the outcomes of deceased donor liver transplantation: a single-center experience

Abstract

Background: The model for end-stage liver disease (MELD)-based allocation system replaced the Child-Turcotte-Pugh (CTP) score-based system for organ allocation of the liver in Korea. The aim of this study is to analyze the changes of outcomes and to describe arising issues before and after the MELD system. Methods: From June 2014 to June 2018, 129 patients were selected from recipients who underwent deceased donor liver trans plantation (DDLT) in Seoul National University Hospital. Pediatric cases were excluded. Patients were divided into two groups according to the allocation system (52 in the MELD group, 77 in the CTP group). Results: The MELD score of the two groups differed significantly (37.8±2.0 in the MELD group, 31.0±8.2 in the CTP group, P=0.001). The etiology of patients was changed the difference in etiology for liver transplantation, proportion of alcoholic cirrho sis is increased in the era of MELD allocation system. However, the proportion of hepatitis B related liver cirrhosis and hepato cellular carcinoma were decreased. Long-term survival rate in CTP group was 80.1% but it was decreased to 75% in MELD group. There were no differences of the complication rate in the CTP group and MELD group (35% vs. 31%). Conclusions: The MELD allocation system distributes the liver to severely ill patients, resulting in poor performance after surgery, and as proportion of alcoholic cirrhosis increase, problems such as re-drink failure may become an issue in the future. It is nec essary to adjust MELD allocation system for increasing outcomes after DDLT.