Abstract
4518 Background: Previous studies have identified several long-term complications following cisplatin-based treatment in testicular cancer survivors (TCS). We evaluated the impact of long-term serum levels of platinum (Pt) on neuro- and ototoxicity (NTX), cardiovascular disease (CVD) and hypogonadism in TCS. Methods: 292 cisplatin-treated TCS (1980-1994) participated in a national follow-up study (2007-2008), including laboratory tests and a questionnaire. Serum Pt was quantified by Inductively Coupled Plasma-Mass Spectrometry. Symptoms of NTX were assessed with Scale for Chemotherapy-Induced Neurotoxicity (SCIN), with each symptom categorized in 4 categories ranging from 0, “not at all” to 3, “very much”. Total SCIN score was the sum of six scores, ranging from 0 to 18, and categorized into quartiles. Information about CVD (validated) and medication were retrieved from the questionnaire. Hypogonadism was defined as using testosterone substitution and/or having testosterone <10nmol/l. Associations between...
Published Version
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