Abstract
ObjectiveTo study the temporal trends in cytologic detection of cervical epithelial cell abnormalities (ECA) and to evaluate the impact of introduction of endocervical brush sampling on detection of ECA. Study designThis was a cross-sectional study of conventional cervical smears collected over a 13 year period (2006–2018). The study was divided into two time periods (TP)-TP1 (2006−2014, 67,437 smears) using only extended tip Ayre’s spatula and TP2 (2015−2018; 36,746 smears) when Cytobrush Papsmear kit (Ayre’s spatula + endocervical brush) was used. The unsatisfactory rate and detection rate of ECA was compared between the two TPs. ResultsThe unsatisfactory rate reduced from 4.7 % in TP 1–1.5% in TP2 (P < 0.001). The frequency of ECA was 1.5 % in TP1 and 1.9 % in TP2 (P < 0.001). A significantly higher number of ASC-H and HSIL were detected in TP2. There was a substantial improvement (3.7 times) in detection of glandular abnormalities overall (P < 0.001), as also for both the qualifiers AGC- NOS (4.4 times) and AGC- FN (3.3 times) in TP2. ConclusionsCervical sampling using combined spatula and endocervical brush reduces the unsatisfactory rate and improves the detection of both squamous and glandular precancerous lesions. Hence, this sampling procedure should be recommended for all laboratories practicing conventional cervical cytology.
Published Version
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