Abstract
To compare unsatisfactory rates and detection of abnormal cervical cytology between conventional cytology or Papanicolaou smear (CC) and liquid-based cytology (LBC). A total of 23,030 cases of cervical cytology performed at King Chulalongkorn Memorial Hospital during 2012-2013 were reviewed. The percentage unsatisfactory and detection rates of abnormal cytology were compared between CC and LBC methods. There was no difference in unsatisfactory rates between CC and LBC methods (0.1% vs. 0.1%, p = 0.84). The detection rate for squamous cell abnormalities was significantly higher with the LBC method (7.7% vs. 11.5%, p < 0.001), but those for overall abnormal glandular epithelium were similar (0.4% vs. 0.6%, p = 0.13). Low grade squamous lesion (ASC-US and LSIL) were more frequently detected by the LBC method (6.1% vs. 9.5%, p < 0.001). However, there was no difference in high gradd squamous lesions (1.1% vs. 1.1%, p = 0.95). When comparing between types of glandular abnormality, there was no significant difference the groups. There was no difference in unsatisfactory rates between the conventional smear and LBC. However, LBC could detect low grade squamous cell abnormalities more than CC, while there were similar rates of detection of high grade squamous cell lesions and glandular cell abnormalities.
Highlights
Cervical cancer is the second most common cancer and cause of death among women worldwide, especially in developing country (Canda, et al, 2009)
It has been reported that the liquid-based cytology (LBC) method can significantly reduce in the number of unsatisfactory specimens from 4.3-11.5% by cytology or Papanicolaou smear (CC) to only 0.3-1.7% by LBC (Davey, et al, 2006, Akamatsu, et al, 2012, Singh, et al, 2015)
CC is a very good method for cervical cancer screening as it needs non-expensive equipment for processing and evaluation, which is suitable for the developing countries that have a very limited resource
Summary
Cervical cancer is the second most common cancer and cause of death among women worldwide, especially in developing country (Canda, et al, 2009). In Thailand, the leading cancer in female population is cervical cancer (Wilailak, 2009). Morbidity and mortality of cervical cancer can be reduced by early detection of precancerous lesion. There are several methods of cervical cytology screening, such as cervical cytology and human papilloma virus (HPV) test. Among these tests, cervical cytology is widely used because it is performed and causes less expense. The cervical cytology can be divided into two types: conventional cytology (CC) and liquid based cytology (LBC)
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