Impact of Intrauterine Injection of Human Chorionic Gonadotropin at Embryo Transfer on Intra Cytoplasmic Sperm Injection Outcome

Abstract

Background: for successful embryonic implantation, a healthy embryo at blastocyst stage and a functional endometrium ready to receive it are basic requirements. There is growing research evidence that reveals the importance of embryonic endometrial synchrony for the accomplishment of a successful conception. Objectives: The aim of this research study is to assess the impact of hCG intrauterine injection procedure before embryonic transfer on enhancing pregnancy and implantation rates. Patients and methods: a prospective randomized clinical research trial that was conducted on 600 cases undergoing embryo transfer via an ICSI program at the ART unit of the International Islamic Centre for Population Studies and Research (IICPSR), Al Azhar University. Cases were categorised randomly into 2 research groups. In the first group (study research group), intrauterine of 500 IU HCG were injected before the embryonic transfer procedure. The second group (control research group), has gone through embryonic transfer without prior injection of hCG. Results: chemical and clinical pregnancy rates were statistically significantly more frequent among research study group (HCG intra uterine injection group).In addition multiple pregnancy was statistically significantly higher within research study group. Implantation Rate was statistically significantly higher among study group. Interestingly no statistical significant difference between study and control groups as regards early and late ovarian hyper-stimulation. Conclusion: there is a possible role of HCG in enhancing and improving endometrial receptivity and increasing implantation and pregnancy rates. Future research efforts should consider racial, ethnic and genetic differences in response to HCG intrauterine injection.