Abstract
Prognosis of advanced stages of laryngeal squamous cell carcinoma (LSCC) remains poor. To clarify therapeutic targets and improve survival rate, identification of new specific and prognostic biomarkers of LSCC is required. The study aimed to evaluate the impact of IL-10:rs1800871, rs1800872, rs1800896 single nucleotide polymorphisms (SNPs), and IL-10 serum levels on LSCC development and determine associations of selected SNPs with patient survival rate. A total of 300 LSCC patients and 533 controls were included in the study. Genotyping was carried out using RT-PCR; IL-10 serum levels were analyzed by ELISA. Significant associations were identified between IL-10 rs1800871 variants and advanced stage of LSCC patient group in the codominant, recessive and additive models (OR=0.473, p=0.027; OR=0.510, p=0.040; and OR=0.733; p=0.037). Significant variants of IL-10 rs1800872 were determined in the codominant, recessive and additive models (OR=0.473, p=0.027; OR=0.510, p=0.040; and OR=0.733, p=0.037). The distribution of IL-10 SNPs genotypes did not impact LSCC patient survival rate (respectively, p=0.952; p=0.952; p=0.991). IL-10:rs1800871 and rs1800872 SNPs are associated with advanced stage of LSCC. The genotypic distribution of IL-10 SNPs does not influence the survival rate of LSCC patients.
Highlights
Laryngeal squamous cell carcinoma (LSCC) represents the largest subgroup of head and neck squamous cell carcinoma (HNSCC) and is one of the most common tumors in the respiratory system [1]
The results demonstrated that genotypes of single nucleotide polymorphisms (SNPs) in the control group did not deviate from Hardy-Weinberg equilibrium (HWE) (p>0.05) (Table II)
We performed genotyping of IL-10: rs1800872, rs1800871, and rs1800896 SNPs in 833 subjects (300 LSCC patients and 533 control group subjects) and studied possible associations between selected SNPs and LSCC development
Summary
Laryngeal squamous cell carcinoma (LSCC) represents the largest subgroup of head and neck squamous cell carcinoma (HNSCC) and is one of the most common tumors in the respiratory system [1]. Various studies have demonstrated a positive correlation between IL-10 levels in serum and tumor tissues and a poor prognosis in melanoma, lung cancer, T/NK cells lymphomas, and HNSCC [22,23,24,25,26]. Previous studies suggested that tumor cells can produce IL-10 by themselves, and IL-10 might be a potential biomarker for IL-10-targeted therapy leading to the conclusion that antagonists of IL-10 might be used as a novel treatment of cancer patients [22,23,24,25, 27, 28]. The objective of this study was to evaluate the impact of IL-10: rs1800871, rs1800871, and rs1800896 SNPs and IL10 serum levels on LSCC development and to determine possible associations of selected SNPs with the survival rate of LSCC patients
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